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Trialkyl Methanetricarboxylate as Dialkyl Malonate Surrogate in Copper-Catalyzed Enantioselective Propargylic Substitution

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journal contribution
posted on 02.10.2015, 00:00 by Guanxin Huang, Cang Cheng, Luo Ge, Beibei Guo, Long Zhao, Xiaoyu Wu
The first copper-catalyzed enantioselective propargylation of trialkyl methantricarboxylate with propargylic alcohol derivatives was developed. The tricarboxylate unit in the obtained adducts could be easily transformed into a malonate moiety by treating with in situ generated NaOEt in excellent yield without racemization.