posted on 2020-08-21, 22:44authored byWenqian Yu, Junlin Sun, Feng Liu, Shuyi Yu, Jialing Hu, Yun Zhao, Xiuyuan Wang, Xiaoqing Liu
Although
immunotherapy has merged as an ideal cancer therapeutic
strategy for preventing tumor growth and recurrence, effective approaches
to treat immunologically cold tumors are still lacking. Herein, we
reported a practical and extendable nanoplatform (HA/ZIF-8@ICG@IMQ)
that facilely integrated various therapeutics and functions for boosting
host antitumor immunity to treat immunologically cold tumors. The
tumor-targeted and microenvironment-responsive HA/ZIF-8@ICG@IMQ facilitated
the tumor-specific accumulation and release of photothermal agents
and immune adjuvants. With near-infrared irradiation, the designed
nanoparticles effectively enhanced the infiltration of cytotoxic T
lymphocytes and helper T cells and effectively blocked the growth
of primary and distant tumors. Moreover, the smart therapeutic could
effectively prevent tumor rechallenge and recurrence with a long-term
host immunological memory response. This method shows an effective
immunologically cold tumor treatment using extendable nanotherapeutics
and may have reference significance for clinical cancer therapy.