Treasures from the Deep: Characellides as Anti-Inflammatory Lipoglycotripeptides from the Sponge Characella pachastrelloides
journal contributionposted on 20.12.2018, 00:00 by Sam Afoullouss, Kevin Calabro, Grégory Genta-Jouve, Sandra Gegunde, Amparo Alfonso, Robert Nesbitt, Christine Morrow, Eva Alonso, Luis M. Botana, A. Louise Allcock, Olivier P. Thomas
The chemical investigation of marine invertebrates from the deep Northeastern Atlantic revealed new lipoglycotripeptides named characellides isolated from the tetractinellid sponge Characella pachastrelloides. This new family of natural products features a central tripeptide linked to a rare sugar unit and a long alkyl chain ending with a 2,3-dimethyltetrahydropyran. The configurations of all 13 chiral centers were determined by extensive use of NMR data and circular dichroism spectra combined with calculations.
Read the peer-reviewed publication
Treasurecharacellidemarine invertebratesconfigurationAnti-Inflammatory Lipoglycotripeptidescalculationdichroism spectraNortheastern Atlanticchemical investigationNMR dataproducts featuresdimethyltetrahydropyranSponge Characella pachastrelloidestetractinellid sponge Characella pachastrelloideslipoglycotripeptideDeepCharacellidealkyl chain13 chiral centerssugar unit