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Transition-Metal-Catalyzed Chemoselective Methylenation of Dicarbonyl Substrates

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journal contribution
posted on 05.09.2008, 00:00 authored by Hélène Lebel, Michaël Davi, Grzegorz T. Stokłosa
Rhodium- and copper-catalyzed methylenation reactions with trimethylsilyldiazomethane, triphenylphosphine, and 2-propanol were used to react chemoselectively with aldehydes, alkoxymethylketones, and trifluoromethylketones in substrates also containing a less reactive carbonyl group. Terminal alkenes were obtained in high yields, and no protecting group was necessary in the methylenation process.