The
direct synthesis of C(CF3)Me2-substituted
heteroarenes by decarboxylative 1,1-dimethyltrifluoroethylation of
heteroarenes with 3,3,3-trifluoro-2,2-dimethylpropanoic acid is reported.
This method does not need the transition-metal catalyst, and the base
is crucial for this reaction. A series of previously unknown C(CF3)Me2-containing heteroarenes were obtained in high
yields and have potential applications in the drug discovery process.