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Transition-Metal-Free Alkynylation of 2‑Oxindoles through Radical–Radical Coupling

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journal contribution
posted on 07.02.2017, 00:00 by Hong-Yan Huang, Liang Cheng, Jie-Jie Liu, Dong Wang, Li Liu, Chao-Jun Li
An effective transition-metal-free approach for the synthesis of 3-alkynyl-2-oxindoles through a radical–radical coupling process was developed. The reaction was general with respect to 2-oxindoles and iodoalkynes and provided the desired products bearing a quaternary center at C3 in good to excellent yields, making this method synthetically viable and attractive for the synthesis of spiro and fused 2-oxindole derivatives.

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