ja409663q_si_001.pdf (10.37 MB)
Download fileTransforming Suzuki–Miyaura Cross-Couplings of MIDA Boronates into a Green Technology: No Organic Solvents
journal contribution
posted on 27.11.2013, 00:00 authored by Nicholas
A. Isley, Fabrice Gallou, Bruce H. LipshutzNew technology has been developed
that enables Suzuki–Miyaura
couplings involving widely utilized MIDA boronates to be run in water
as the only medium, mainly at room temperature. The protocol is such
that no organic solvent is involved at any stage; from the reaction
through to product isolation. Hence, using the E factor
scale as a measure of greenness, the values for these cross-couplings
approach zero.