Transformation of Alkynes into Chiral Alcohols via
TfOH-Catalyzed Hydration and Ru-Catalyzed Tandem Asymmetric Hydrogenation

Liu, Sensheng; Liu, Huan; Zhou, Haifeng; Liu, Qixing; Lv, Jinliang

doi:10.1021/acs.orglett.8b00034.s001

ol8b00034_si_001.pdf (2.42 MB)

Transformation of Alkynes into Chiral Alcohols via TfOH-Catalyzed Hydration and Ru-Catalyzed Tandem Asymmetric Hydrogenation

journal contribution

posted on 2018-01-25, 16:04 authored by Sensheng Liu, Huan Liu, Haifeng Zhou, Qixing Liu, Jinliang Lv

A novel full atom-economic process for the transformation of alkynes into chiral alcohols by TfOH-catalyzed hydration coupled with Ru-catalyzed tandem asymmetric hydrogenation in TFE under simple conditions has been developed. A range of chiral alcohols was obtained with broad functional group tolerance, good yields, and excellent stereoselectivities.