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Transfer Hydrogenation in Water: Enantioselective, Catalytic Reduction of (E)-β,β-Disubstituted Nitroalkenes

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journal contribution
posted on 2009-09-17, 00:00 authored by Omid Soltani, Martin A. Ariger, Erick M. Carreira
A mild catalytic asymmetric transfer hydrogenation of β,β-disubstituted nitroalkenes is reported. Formic acid is used as a reductant in combination with an Ir catalyst. The reaction is conducted in water at low pH and open to air to give adducts in preparatively useful yield and selectivity.