ol016314o_si_001.pdf (62.63 kB)
Total Synthesis of the Sesquiterpene (±)-Illudin C via an Intramolecular Nitrile Oxide Cycloaddition
journal contributionposted on 2001-07-06, 00:00 authored by Ronald A. Aungst, Collin Chan, Raymond L. Funk
A convergent total synthesis of illudin C is described. The tricyclic ring system of the natural product was quickly assembled from cyclopropane and cyclopentene precursors via a novel oxime dianion coupling reaction and a subsequent intramolecular nitrile oxide−olefin cycloaddition.