posted on 2024-01-11, 14:13authored bySukhyun Lee, Young Ho Rhee
The first total synthesis of the
purported structure of branched
resin glycosides merremoside G and H2 is accomplished.
A signature step is represented by the sequential transition-metal-catalyzed
coupling of stable trisaccharide homoallylic alcohol and monosaccharide
alkoxyallene to afford the pentasaccharide skeleton. This de novo strategy is conducted under mild conditions with
no need of preactivation. In addition, it allows for efficient preparation
of the target compounds in combination with late-stage functionalization.