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Total Synthesis of the Proposed Structure of Characellide B

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journal contribution
posted on 27.04.2021, 14:04 by Yong Wang, Zhenwei Wang, Zhe Wang, Xiaoyu Liu, Yingjun Jiang, Xiaozhen Jiao, Ping Xie
We achieved the total synthesis of the proposed structure of characellide B, a novel lipoglycotripeptide. Comparison of the data for the synthetic compound with those for the natural product indicated some possible errors in the original structural assignment. Furthermore, we synthesized the other four stereoisomers, focusing on the d-Asp-d-allo-Thr fragment, to determine the actual structure of characellide B. Nevertheless, the data for the stereoisomers were not consistent with those for the natural product.