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Total Synthesis of the Highly Potent Anti-HIV Natural Product Daurichromenic Acid along with Its Two Chromane Derivatives, Rhododaurichromanic Acids A and B

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journal contribution
posted on 13.11.2003, 00:00 by Ying Kang, Yan Mei, Yuguo Du, Zhendong Jin
The highly potent anti-HIV natural product daurichromenic acid was successfully synthesized in only five steps with 49% overall yield. The key step in the synthetic strategy involves a microwave-assisted tandem condensation and intramolecular SN2‘-type cyclization to form the 2H-benzopyran core structure.