Total Synthesis of the Diazobenzofluorene Antibiotic (−)-Kinamycin C

Lei, Xiaoguang; Porco, John A.

doi:10.1021/ja066621v.s002

ja066621v_si_002.pdf (3.01 MB)

Total Synthesis of the Diazobenzofluorene Antibiotic (−)-Kinamycin C

journal contribution

posted on 2006-11-22, 00:00 authored by Xiaoguang Lei, John A. Porco

The enantioselective total synthesis of the diazobenzofluorene antibiotic (-)-kinamycin C is reported. The approach involves tartrate-mediated, asymmetric nucleophilic epoxidation of a functionalized quinone monoketal to construct the highly substituted D-ring.