American Chemical Society
ja066621v_si_002.pdf (3.01 MB)

Total Synthesis of the Diazobenzofluorene Antibiotic (−)-Kinamycin C

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journal contribution
posted on 2006-11-22, 00:00 authored by Xiaoguang Lei, John A. Porco
The enantioselective total synthesis of the diazobenzofluorene antibiotic (-)-kinamycin C is reported. The approach involves tartrate-mediated, asymmetric nucleophilic epoxidation of a functionalized quinone monoketal to construct the highly substituted D-ring.