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Total Synthesis of the Antifungal Depsipeptide Petriellin A

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journal contribution
posted on 19.08.2011, 00:00 by Marianne M. Sleebs, Denis Scanlon, John Karas, Rani Maharani, Andrew B. Hughes
We report the solid-phase total synthesis of the antifungal highly modified cyclic depsipeptide petriellin A. The synthesis confirms earlier reports on the absolute configuration of the natural product. The solid-phase approach resulted in a protected linear precursor, which was cleaved from the solid support prior to cyclization and final deprotection. Use of advanced coupling agents for several hindered amides was a feature of the synthesis. The natural product was prepared in overall 5% yield.