posted on 2000-02-04, 00:00authored byEmily M. Stocking, Juan F. Sanz-Cervera, Robert M. Williams
The total synthesis of VM55599, a natural metabolite of Penicillium sp. IMI332995, has been achieved
via an intramolecular Diels−Alder cycloaddition of a reverse isoprene moiety across an azadiene system. The
diastereoselectivity of the intramolecular Diels−Alder cycloaddition has biogenetic implications and is discussed
in the context of the biogenetic relationship of VM55599 to the paraherquamides.