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Total Synthesis of Sordaricin

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journal contribution
posted on 28.03.2003, 00:00 by Lewis N. Mander, Regan J. Thomson
The total synthesis of sordaricin, the diterpene aglycone of an important class of antifungal compounds, is described. Two approaches were explored, the first of which utilized a possible biogenetic intramolecular [4 + 2] cycloaddition to form the complete carbon skeleton of the target molecule. A second approach using a tandem cycloreversion/intramolecular [4 + 2] cycloaddition sequence is also detailed.