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Total Synthesis of (±)-Rhazinal Using Novel Palladium-Catalyzed Cyclizations

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journal contribution
posted on 20.02.2009, 00:00 by Alfred L. Bowie, Dirk Trauner
A concise synthesis of (±)-rhazinal that hinges on novel oxidative Heck cyclizations and palladium-catalyzed direct couplings is described. An X-ray structure of N-MOM-rhazinal, which provides insight into the conformation of the strained 9-membered lactam ring, is described.

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