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Download fileTotal Synthesis of Reveromycin A
journal contribution
posted on 23.06.2000, 00:00 by Takeshi Shimizu, Tsutomu Masuda, Katsuya Hiramoto, Tadashi NakataThe stereoselective total synthesis of reveromycin A (1), a potent inhibitor of eukaryotic cell growth, has been accomplished on the basis of
the stereocontrolled construction of the 6,6-spiroketal system, efficient succinylation of the tert-alcohol under high pressure, and the introduction
of the unsaturated side chains.
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