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Total Synthesis of Resiniferatoxin

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journal contribution
posted on 2022-08-31, 14:07 authored by Vasil H. Vasilev, Lukas Spessert, Kuan Yu, Thomas J. Maimone
From both structural and functional perspectives, the large family of daphnane diterpene orthoesters (DDOs) represent a truly remarkable class of natural products. As potent lead compounds for the treatment of pain, neurodegeneration, HIV/AIDS, and cancer, their medicinal potential continues to be heavily investigated, yet synthetic routes to DDO natural products remain rare. Herein we report a distinct approach to this class of complex diterpenes, highlighted by a 15-step total synthesis of the flagship DDO, resiniferatoxin.

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