Total Synthesis of Potential Antitumor Agent, (−)-Dictyostatin
journal contributionposted on 04.01.2007, 00:00 by P. Veeraraghavan Ramachandran, Amit Srivastava, Debasis Hazra
The potential antitumor agent (−)-dictyostatin has been synthesized utilizing Brown crotylboration to achieve eight of the eleven chiral centers. The yield for the 26-step longest sequence is ∼4%. The C9−C10 coupling is achieved via a stereoselective vinylzincate addition.