Total Synthesis of Phenalamide A2

Hoffmann, Reinhard W.; Rohde, Thorsten; Haeberlin, Eckart; Schäfer, Frank

doi:10.1021/ol990944x.s001

Total Synthesis of Phenalamide A₂

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posted on 1999-11-02, 00:00 authored by Reinhard W. Hoffmann, Thorsten Rohde, Eckart Haeberlin, Frank Schäfer

Phenalamide A₂ (1b) has been synthesized for the first time. The synthesis features the homologation of aldehyde 5 to trienal 3 with the new conjunctive reagent 6 and the formation of amide 14 with the functionalized Horner−Emmons reagent 4.

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trienal 3 functionalized 2 Phenalamide amide 14 homologation synthesis features formation Horner conjunctive reagent 6 Total Synthesis aldehyde 5 1 b

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Total Synthesis of Phenalamide A₂

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