American Chemical Society
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Total Synthesis of Natural p‑Quinol Cochinchinenone

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journal contribution
posted on 2012-12-07, 00:00 authored by Silvia Barradas, Gloria Hernández-Torres, Antonio Urbano, M. Carmen Carreño
Cochinchinenone has been synthesized in only five steps and four pots and in 58% overall yield from commercially available 2,3-dimethoxy-4-hydroxy-benzaldehyde and OPMB-protected p-hydroxy acetophenone, the key step being the oxone-mediated oxidative dearomatization of the corresponding ketone-containing p-substituted phenol.