ol0c03308_si_001.pdf (4.91 MB)
Total Synthesis of Meayamycin and O‑Acyl Analogues
journal contributionposted on 2020-10-19, 21:10 authored by Christopher Gartshore, Shinji Tadano, Prem B. Chanda, Anindya Sarkar, Naidu S. Chowdari, Sanjeev Gangwar, Qian Zhang, Gregory D. Vite, Jelena Momirov, Dale L. Boger
A short, scalable total synthesis of meayamycin is described by an approach that entails a longest linear sequence of 12 steps (22 steps overall) from commercially available chiral pool materials (ethyl l-lactate, BocNH-Thr-OH, and d-ribose) and introduces the most straightforward preparation of the right-hand subunit detailed to date. The use of the approach in the divergent synthesis of a representative series of O-acyl analogues is exemplified.