Total Synthesis of (−)-Lycorine and (−)-2-epi-Lycorine by Asymmetric Conjugate Addition Cascade

Total syntheses of (−)-lycorine and (−)-2-epi-lycorine were accomplished using chiral ligand-controlled asymmetric cascade conjugate addition methodology, which enables the formation of two C−C bonds and three stereogenic centers in one pot to give synthetically useful chiral cyclohexane derivatives.