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Download fileTotal Synthesis of (−)-Lycorine and (−)-2-epi-Lycorine by Asymmetric Conjugate Addition Cascade
journal contribution
posted on 2009-04-02, 00:00 authored by Ken-ichi Yamada, Mitsuaki Yamashita, Takaaki Sumiyoshi, Katsumi Nishimura, Kiyoshi TomiokaTotal syntheses of (−)-lycorine and (−)-2-epi-lycorine were accomplished using chiral ligand-controlled asymmetric cascade conjugate addition methodology, which enables the formation of two C−C bonds and three stereogenic centers in one pot to give synthetically useful chiral cyclohexane derivatives.