Total Synthesis of (−)-Huperzine A

Koshiba, Takahiro; Yokoshima, Satoshi; Fukuyama, Tohru

doi:10.1021/ol9022408.s002

ol9022408_si_002.pdf (1.65 MB)

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Total Synthesis of (−)-Huperzine A

journal contribution

posted on 2009-11-19, 00:00 authored by Takahiro Koshiba, Satoshi Yokoshima, Tohru Fukuyama

The total synthesis of (−)-huperzine A was accomplished in 23 steps from a commercially available anhydride. Our synthetic route features a facile construction of the bicyclo[3.3.1] skeleton equipped with proper functionalities to introduce the remaining substructures.

Total Synthesis of (−)-Huperzine A

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