American Chemical Society
ol9022408_si_002.pdf (1.65 MB)
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Total Synthesis of (−)-Huperzine A

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journal contribution
posted on 2009-11-19, 00:00 authored by Takahiro Koshiba, Satoshi Yokoshima, Tohru Fukuyama
The total synthesis of (−)-huperzine A was accomplished in 23 steps from a commercially available anhydride. Our synthetic route features a facile construction of the bicyclo[3.3.1] skeleton equipped with proper functionalities to introduce the remaining substructures.