Total Synthesis of Hirsutellone B via Ullmann-Type Direct 13-Membered Macrocyclization
journal contributionposted on 02.12.2011, 00:00 by Hiromi Uchiro, Ryo Kato, Yuuki Arai, Miki Hasegawa, Yu Kobayakawa
Total synthesis of Hirsutellone B has been achieved by a convergent synthetic strategy. This synthesis features direct construction of the highly strained 13-membered macrocycle of Hirsutellone B utilizing the Ullmann-type reaction. To the best of our knowledge, this is the first application of macrocyclization utilizing an intramolecular Ullmann-type reaction between an aliphatic alcohol and aryl halide.