posted on 2024-03-01, 17:48authored byFabian Schneider, Yinliang Guo, You-Chen Lin, Kelly J. Eberle, Debora Chiodi, Johnathan A. Greene, Chenxin Lu, Phil S. Baran
The first total synthesis of the potent antimicrobial
agent dynobactin
A is disclosed. This synthesis enlists a singular aziridine ring opening
strategy to access the two disparate β-aryl-branched amino acids
present within this complex decapeptide. Featuring a number of unique
maneuvers to navigate inherently sensitive and epimerizable functional
groups, this convergent approach proceeds in only 16 steps (LLS) from
commercial materials and should facilitate the synthesis of numerous
analogues for medicinal chemistry studies.