ol9023437_si_001.pdf (4.28 MB)
Download file

Total Synthesis of (±)-Cordypyridones A and B and Related Epimers

Download (4.28 MB)
journal contribution
posted on 03.12.2009, 00:00 by Ian L. Jones, Felicity K. Moore, Christina L. L. Chai
Efficient racemic synthesis of two antibacterial and antimalarial natural products, cordypyridones A and B, was achieved from inexpensive, commercially available starting materials in an overall yield of 15% (8% and 7%, respectively). This convergent synthesis utilizes a key coupling step of two fragments and the subsequent functional group transformations lead to the target compounds and their 8-epi-analogues.

History