American Chemical Society
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Total Synthesis of (±)-Clavubicyclone

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journal contribution
posted on 2006-10-12, 00:00 authored by Hisanaka Ito, Shunta Takeguchi, Takahiro Kawagishi, Kazuo Iguchi
The total synthesis of racemic clavubicyclone (1), which was isolated from Okinawan soft coral by our group, is described. The bicyclo[3.2.1]octane skeleton was prepared by Cope rearrangement of a divinylcyclopropane derivative. Three functional groups on the skeleton were constructed by Barton decarboxylation, Wittig reaction, and alkylation.

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