Total Synthesis of (−)-Brevisin: A Concise Synthesis of a New Marine Polycyclic Ether
journal contributionposted on 18.02.2011, 00:00 by Takefumi Kuranaga, Naohito Ohtani, Ryosuke Tsutsumi, Daniel G. Baden, Jeffrey L. C. Wright, Masayuki Satake, Kazuo Tachibana
The first and highly efficient total synthesis of (−)-brevisin has been achieved. The title compound was synthesized in only 29 steps (longest linear sequence) from commercially available starting materials. The synthesis provided over 70 mg of a marine polycyclic ether compound.