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Total Synthesis of Asperphenins A and B

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journal contribution
posted on 19.09.2018, 20:47 by Jia-Lei Yan, Yingying Cheng, Jing Chen, Ranjala Ratnayake, Long H. Dang, Hendrik Luesch, Yian Guo, Tao Ye
The first total synthesis of asperphenins A and B has been accomplished in a concise, highly stereoselective fashion from commercially available materials (15 steps, 9.7% and 14.2% overall yields, respectively). The convergent route featured the judicious choice of protecting groups, fragment assembly strategy and a late-stage iron-catalyzed Wacker-type selective oxidation of an internal alkene to the corresponding ketone.