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Total Synthesis of Amphidinolide E

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journal contribution
posted on 20.12.2006, 00:00 by Porino Va, William R. Roush
A convergent and highly stereocontrolled synthesis of amphidinolide E (1) has been accomplished. The synthesis features a highly diastereoselective (>20:1) BF3·Et2O promoted [3+2] annulation reaction between aldehyde 3 and allylsilane 4 to afford substituted tetrahydrofuran 2.