Total Synthesis of Agelagalastatin
journal contributionposted on 31.08.2006, 00:00 by Yong Joo Lee, Bo-Young Lee, Heung Bae Jeon, Kwan Soo Kim
The total synthesis of agelagalastatin, an antineoplastic glycosphingolipid, has been achieved. The synthesis involved an α-selective glycosylation of the ceramide moiety with the trisaccharide fluoride. The trisaccharide component was constructed employing the CB glycoside method which permitted a completely α-stereoselective galactofuranosylation.