Total Synthesis of (±)-Thebainone A by Intramolecular
Nitrone Cycloaddition

Wang, Yuzhou; Hennig, André; Küttler, Thomas; Hahn, Christian; Jäger, Anne; Metz, Peter

doi:10.1021/acs.orglett.0c00905.s001

Total Synthesis of (±)-Thebainone A by Intramolecular Nitrone Cycloaddition

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posted on 2020-04-06, 13:33 authored by Yuzhou Wang, André Hennig, Thomas Küttler, Christian Hahn, Anne Jäger, Peter Metz

Using an intramolecular nitrone cycloaddition and a Heck cyclization as the crucial transformations, a total synthesis of the racemic morphine alkaloid thebainone A was accomplished in 22 steps commencing with isovanillin.

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Keywords

intramolecular nitrone cycloaddition racemic morphine alkaloid thebainone isovanillin Heck cyclization Intramolecular Nitrone Cycloaddition transformation synthesis 22 steps Thebainone Total Synthesis

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