American Chemical Society
ol034856v_si_001.pdf (445.42 kB)

Total Synthesis of (±)-Spiroxin C

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journal contribution
posted on 2003-07-03, 00:00 authored by Kazuyuki Miyashita, Takayuki Sakai, Takeshi Imanishi
The first total synthesis of a marine-derived potent antitumor antibiotic, (±)-spiroxin C, was achieved via a TBAF-activated Suzuki−Miyaura cross-coupling reaction as a key step, which was also shown to be useful for the synthesis of sterically hindered binaphthyl derivatives.