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Total Synthesis of (+)-Medicarpin

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journal contribution
posted on 21.11.2017, 20:33 by Xiaoming Yang, Yu Zhao, Min-Tsang Hsieh, Guang Xin, Rong-Tsun Wu, Pei-Lun Hsu, Lin-Yea Horng, Hui-Ching Sung, Chien-Hsin Cheng, Kuo-Hsiung Lee
(+)-Medicarpin has been synthesized asymmetrically for the first time in a linear scalable process with an overall yield of 11%. The two chiral centers were constructed in one step via condensation using a chiral oxazolidinone auxiliary. This method will likely accelerate research on medicarpin as an erythropoietin inducer for erythropoietin-deficient diseases.