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Total Synthesis of (±)-Cylindricines A and B

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journal contribution
posted on 14.10.1999, 00:00 by Julie Fields Liu, Clayton H. Heathcock
Cylindricine A (1) and cylindricine B (2) have been synthesized in 11 steps and 19% overall yield. The key reaction involves the addition of an organocopper species to a bicyclic vinylogous amide, which provides complete stereocontrol over the installation of the hexyl side chain.