jo991020q_si_001.pdf (1.16 MB)

Total Synthesis of (±)-Cylindricines A and B

Download (1.16 MB)
journal contribution
posted on 14.10.1999, 00:00 by Julie Fields Liu, Clayton H. Heathcock
Cylindricine A (1) and cylindricine B (2) have been synthesized in 11 steps and 19% overall yield. The key reaction involves the addition of an organocopper species to a bicyclic vinylogous amide, which provides complete stereocontrol over the installation of the hexyl side chain.

History