American Chemical Society
jo6b01435_si_001.pdf (1.5 MB)

Total Synthesis of (−)-Carinatine A and (+)-Lycopladine A

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journal contribution
posted on 2016-08-02, 00:00 authored by Lingxing Meng
An efficient synthesis of two Lycopodium alkaloids, (−)-carinatine A and (+)-lycopladine A, is achieved in eight steps. The synthesis features an intramolecular aldol reaction for assembling the 6,5-fused ring system, a subsequent Tsuji-Trost allylation for generating a quarternary carbon center, and a 6π-electrocyclization to form the pyridine ring.