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Total Synthesis of (−)-Callystatin A

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journal contribution
posted on 17.04.2001, 00:00 authored by Amos B. Smith, Benjamin M. Brandt
An effective total synthesis of (−)-callystatin A (1), member of the leptomycin family of antibiotics, has been achieved. The synthesis features Evans extended aldol methodology to construct the northern polypropionate subunit and two separate Julia olefinations to assemble the conjugated dienes. The total synthesis proceeded in 2.3% overall yield with the longest linear sequence of 15 steps.