Total Synthesis and Structural Confirmation of the Marine Natural Product Dysinosin A: A Novel Inhibitor of Thrombin and Factor VIIa
journal contributionposted on 2002-10-17, 00:00 authored by Stephen Hanessian, Roberto Margarita, Adrian Hall, Shawn Johnstone, Martin Tremblay, Luca Parlanti
The structure and absolute configuration of the marine antithrombotic product dysinosin A was confirmed by total synthesis. The strategy involved disconnections to three subunits, of which two were synthesized from the readily available l-glutamic acid, d-leucine, and d-mannitol. The Grubbs olefin metathesis carbocyclization reaction was utilized to prepare two intermediates.