ja0208153_si_003.pdf (222.5 kB)
Download file

Total Synthesis and Structural Confirmation of the Marine Natural Product Dysinosin A:  A Novel Inhibitor of Thrombin and Factor VIIa

Download (222.5 kB)
journal contribution
posted on 17.10.2002, 00:00 by Stephen Hanessian, Roberto Margarita, Adrian Hall, Shawn Johnstone, Martin Tremblay, Luca Parlanti
The structure and absolute configuration of the marine antithrombotic product dysinosin A was confirmed by total synthesis. The strategy involved disconnections to three subunits, of which two were synthesized from the readily available l-glutamic acid, d-leucine, and d-mannitol. The Grubbs olefin metathesis carbocyclization reaction was utilized to prepare two intermediates.

History