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Total Synthesis and Absolute Stereochemistry of Pentenocin B, a Novel Interleukin-1β Converting Enzyme Inhibitor

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journal contribution
posted on 05.03.2004, 00:00 by Tsutomu Sugahara, Hayato Fukuda, Yoshiharu Iwabuchi
Four possible diastereomers of pentenocin B were synthesized in a stereocontrolled manner, and the first total synthesis of a natural enantiomer of (+)-pentenocin B unequivocally established the absolute stereochemistry to be 4S,5R,6R.

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