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Total Synthesis and Absolute Configuration of (−)-Berkeleyamide A

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journal contribution
posted on 05.02.2010, 00:00 by Jonathan Sperry, Eric B. J. Harris, Margaret A. Brimble
A chiral-pool approach to (−)-berkeleyamide A 1 based on a diastereoselective nitrile oxide [3 + 2]-cycloaddition completes the first total synthesis establishing the absolute stereochemistry of the natural product.