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Total Syntheses of Variolin B and Deoxyvariolin B1

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journal contribution
posted on 26.12.2003, 00:00 by Abderaouf Ahaidar, David Fernández, Gerardo Danelón, Carmen Cuevas, Ignacio Manzanares, Fernando Albericio, John A. Joule, Mercedes Álvarez
Two alternative synthetic routes have been developed for the preparation of variolin B and deoxyvariolin B. The strategy is based on the preparation of the core tricyclic ring common to all variolins, pyrido[3‘,2‘:4,5]pyrrolo[1,2-c]pyrimidine, followed by a palladium-catalyzed cross-coupling reaction to give the tetracyclic system.