ol9b02601_si_001.pdf (3.38 MB)
Download fileTotal Syntheses of Pyocyanin, Lavanducyanin, and Marinocyanins A and B
journal contribution
posted on 2019-08-28, 17:41 authored by Haruki Kohatsu, Shogo Kamo, Shusuke Tomoshige, Kouji KuramochiTotal syntheses of
pyocyanin, lavanducyanin, and marinocyanins
A and B have been accomplished. The N-substituted
phenazin-1-one skeleton, a common framework of these natural products,
was constructed through the oxidative condensation of pyrogallol with N-substituted benzene-1,2-diamine under an oxygen atmosphere
in a single step. Regioselective bromination with N-bromosuccinimide at the C-2 position of N-alkylated
phenazin-1-ones afforded brominated natural products.