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Total Syntheses of (+)-Cylindricines C−E and (−)-Lepadiformine through a Common Intermediate Derived from an aza-Prins Cyclization and Wharton's Rearrangement

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journal contribution
posted on 2004-10-28, 00:00 authored by Jia Liu, Richard P. Hsung, Scott D. Peters
Enantioselective total syntheses of (+)-cylindricines C−E and (−)-lepadiformine through a common tricyclic intermediate are described here. These syntheses are concise and feature an aza-Prins cyclization and a seldom-used Wharton rearrangement en route to the common intermediate.

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