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Tobacco Mosaic Virus-Functionalized Mesoporous Silica Nanoparticles, a Wool-Ball-like Nanostructure for Drug Delivery
Version 2 2018-12-27, 18:11
Version 1 2018-12-21, 17:19
journal contribution
posted on 2018-12-21, 00:00 authored by Laura Marín-Caba, Paul L. Chariou, Carmen Pesquera, Miguel A. Correa-Duarte, Nicole F. SteinmetzThe design of versatile tools to
improve cell targeting and drug
delivery in medicine has become increasingly pertinent to nanobiotechnology.
Biological and inorganic nanocarrier drug delivery systems are being
explored, showing advantages and disadvantages in terms of cell targeting
and specificity, cell internalization, efficient payload delivery,
and safety profiles. Combining the properties of a biological coating
on top of an inorganic nanocarrier, we hypothesize that this hybrid
system would improve nanoparticle–cell interactions, resulting
in enhanced cell targeting and uptake properties compared to the bare
inorganic nanocarrier. Toward this goal, we engineered a hierarchical
assembly featuring the functionalization of cargo-loaded mesoporous
silica nanoparticles (MSNPs) with tobacco mosaic virus (TMV) as a
biological coating. The MSNP functions as a delivery system because
the porous structure enables high therapeutic payload capacity, and
TMV serves as a biocompatible coating to enhance cell interactions.
The resulting MSNP@TMV nanohybrids have a wool-ball-like appearance
and demonstrate enhanced cell uptake, hence cargo delivery properties.
The MSNP@TMV have potential for medical applications such as drug
delivery, contrast agent imaging, and immunotherapy.