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Titanocene(III)-Promoted Reformatsky Additions

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journal contribution
posted on 06.09.2003, 00:00 by J. D. Parrish, Daniel R. Shelton, R. Daniel Little
A novel method for the promotion of Reformatsky-like reactions is presented. The technique employs titanocene(III) chloride as a mild and homogeneous single-electron reductant. The reactions are rapid, operationally simple, and compatible with a wide range of functionalities. These additions are also anti diastereoselective.