American Chemical Society
Browse

Titanium Alkoxide-Based Regioselective Alkyne–Alkyne Reductive Coupling Mediated by In Situ Generated Arylamidate

Download (10.62 MB)
journal contribution
posted on 2020-02-17, 17:07 authored by Bin Cai, James S. Panek
Titanium alkoxide-based alkyne–alkyne reductive coupling mediated by in situ generated arylamidate is described. A high level of regioselectivity is achieved in 37 examples, where (E,E)-dienes are exclusively formed. To the best of our knowledge, this study represents the first example of an apparent amide and carbamate directing effect in metal-mediated reductive coupling.

History