Three-Dimensional Heterocycles by 5‑exo-dig
Cyclizations of S‑Methyl‑N‑ynonylsulfoximines

Ma, Ding; Kong, Deshen; Wang, Chenyang; Truong, Khai-Nghi; Rissanen, Kari; Bolm, Carsten

doi:10.1021/acs.orglett.1c03041.s001

ol1c03041_si_001.pdf (3.1 MB)

Three-Dimensional Heterocycles by 5‑exo-dig Cyclizations of S‑Methyl‑N‑ynonylsulfoximines

journal contribution

posted on 2021-10-12, 13:37 authored by Ding Ma, Deshen Kong, Chenyang Wang, Khai-Nghi Truong, Kari Rissanen, Carsten Bolm

Upon treatment with Cs₂CO₃, S-methyl-N-ynonylsulfoximines undergo 5-exo-dig cyclizations to give three-dimensional heterocycles. The reactions proceed at ambient temperature with a wide range of substrates affording the corresponding products in good to excellent yields.